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IrAEs were treated per institutional guidelines

The infusion and vital signs of the patient are continuously monitored by the Doctor-supervised IV therapy

Hypoxia-inducible factor 1 (HIF-1) is a crucial transcription factor modulating the high energy requirements of immune cells to perform their effector functions in low-oxygen states (6770)

Animal research and scarce human studies confirm these findings, showing that disruptions in microbiota composition or metabolite profiles can induce anxiety-like behaviors via MGBA (Cai et al., 2025)